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BARDA, Snapdragon Chemistry Inc., demonstrate deployable domestic manufacturing technology for COVID-19 vaccine component

BARDA Response

Development of rapidly scalable, deployable, platform for U.S.-based continuous manufacturing of NTPs could boost pandemic vaccines production

BARDA and Snapdragon Chemistry Inc. of Waltham, Massachusetts, will work together over the next year to develop and demonstrate an innovative continuous manufacturing platform to produce ribonucleotide triphosphates (NTPs), a critical raw material for COVID-19 vaccines that use messenger RNA technology. The project includes a rapidly scalable, continuous manufacturing process for the chemical synthesis and purification of NTPs.

Messenger RNA (mRNA) is present in all living cells and carries instructions from the DNA (deoxyribonucleic acid) of one cell to another. Currently, one of the COVID-19 vaccines being developed with federal funding use mRNA technology and rely on NTPs.

With a small footprint and low capital cost, multiple identical platforms can be deployed to vaccine manufacturing facilities in the United States, providing a more reliable way of producing the NTP component of some COVID-19 vaccines.

In supporting Operation Warp Speed, BARDA is working to remove any possible barriers to vaccine production and provide the core services and expertise private sector partners need to accelerate development and manufacturing, including improving the U.S.-based production of raw materials.

This award is one component of BARDA’s rapidly expanding COVID-19 medical countermeasure portfolio; visit BARDA’s COVID-19 Portfolio to learn more.

About the Company:

The following information is provided by the company and does not indicate endorsement by the federal government of the company or its products.

Snapdragon Chemistry is a chemical technology company focused on the design and development of efficient and sustainable manufacturing processes for fine chemicals and pharmaceuticals. With our expertise in continuous manufacturing, combined with proprietary R&D technologies and a talented team of scientist and engineers, we deliver highly intensified and controlled manufacturing processes for even the most complex molecules. For more information visit us at:

Last Updated: June 11, 2020