Updated Instructions: Seeking Proposals: Antibacterial Accelerator Broad Agency Announcement Special Instructions

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In 2016, BARDA partnered with international funders to launch what would become the world’s largest early-stage research and development accelerator for new antibacterial products. The goal was to build a diverse, early-stage development portfolio of innovative products to treat, prevent, and diagnose antibiotic-resistant infections.

The five-year program has exceeded the targets set out in the 2015-2020 U.S. National Action Plan for Combating Antibiotic-Resistant Bacteria (CARB) (PDF - 519KB), supporting over 90 projects with 62 active within the portfolio, leading to nine first-in-human clinical studies. BARDA’s $180 million investment in the accelerator was met with an additional $300 million in funding and in-kind services from other donors, and over $1.94 billion in follow-on private sector investment in product developers.

As the initial five-year program comes to a close, the 2020-2025 U.S. National Action Plan for CARB spells out the U.S. government’s commitment to continued support of early-stage development of innovative antibacterial products. Demonstrating that ongoing commitment, today we are launching a set of special instructions to the BARDA Broad Agency Announcement (BAA) to seek proposals for another 10 years of investment through an Antibacterial Accelerator.

This program will continue to be a platform for global partnerships, built on lessons learned over the last five years, to spur innovation and expand the pipeline of early-stage antibacterial candidates. With continued focus on supporting candidate programs to counter the threat of antimicrobial resistance now and in the future, the Antibacterial Accelerator will provide non-dilutive funding and a full suite of research and development support to product developers worldwide.


For more details, check out the updated BARDA BAA Amendment #26, Special Instructions Issuance for the Area of Interest #3.4 Antibacterial Accelerator of the BARDA BAA (BAA-18-100-SOL-00003).

Full proposals may be submitted until 4:30PM ET on Monday, June 28, 2021.

Inquiries for BARDA BAA-18-100-SOL-00003 Amendment #25, Special Instructions for Area of Interest #3.4 Antibacterial Accelerator were collected from May 12, 2021, through May 19, 2021. Responses to inquiries are available here.



For more details, check out the BARDA BAA Amendment #25, Special Instructions Issuance for the Area of Interest #3.4 Antibacterial Accelerator of the BARDA BAA (BAA-18-100-SOL-00003).

Full proposals may be submitted until 4:30PM ET on Monday, June 28, 2021.

BARDA will also provide written responses to inquires received by 4:30PM ET on Wednesday, May 19, 2021.

Last Updated: June 14, 2021